Incentives affecting prescribing, dispensing, and pharmaceutical spending: a scoping review
Main Article Content
Keywords
Health Care System, Healthcare Financing, pharmaceutical policy, Health Expenditure, drugs
Abstract
Introduction: Healthcare systems face significant challenges due to annual cost increases. Incentives beyond the clinical, such as economic, social, and political, affect medical decisions and influence drug prescribing and dispensing, thus impacting pharmaceutical spending, which is essential for financial sustainability of the system and equitable access to treatment. Objective: To identify the incentives that affect drug prescribing and dispensing and pharmaceutical spending worldwide, which seeks to answer our research question. Methods: A quantitative descriptive study based on a systematic literature search in 8 databases and data extraction, coding and categorization to explain and answer the research question. Results: 426 references were screened, 103 of them were accepted as research corpus and from them, through a pre-coding of 497 terms by semantic affinity, similarity, meaning, coincidences or differences and excluding character, 345 open codes were obtained, grouped in 34 open categories, 7 axial categories and 3 selective categories that allow identifying the incentives of the research question. Conclusions: Our research identifies 3 main areas: Health System and Access to Medicines, Prescribing Contexts, and Factors Associated with the Use of Medicines; with 34 categories and 345 factors grouped into 117 main incentives that affect, to varying degrees, the prescribing and dispensing of medicines and that are linked to the pharmaceutical expenditure that health systems worldwide are trying to control. In general, the evidence points to better outcomes when prescriber and patient incentives are addressed, compared with restrictive policies that do not show clear results in therapeutic targeting and health outcomes.
References
2. Stone P. W. (2002). Popping the (PICO) question in research and evidence-based practice. Applied nursing research : ANR, 15(3), 197–198. https://doi.org/10.1053/apnr.2002.34181
3. Sgarbossa, N., Cobaisse, M. I., Cianciulli, G. G., Bracchiglione, J., & Franco, J. V. A. (2022). Systematic reviews: Key concepts for health professionals. Medwave, 22(09), e2622. https://doi.org/10.5867/medwave.2022.09.2622
4. Bonilla-García, M. Á., & López-Suárez, A. D. (2016). Ejemplificación del proceso metodológico de la teoría fundamentada. Cinta de Moebio, 57, 305-315. https://doi.org/10.4067/s0717-554x2016000300006
5. Acuña JS, Percepciones sociales acerca de la posibilidad de implementar una Renta Básica Universal en Colombia. Tesis de doctorado. Universidad Jorge Tadeo Lozano. 2020. https://expeditiorepositorio.utadeo.edu.co/bitstream/handle/20.500.12010/11901/Trabajo%20de%20grado.pdf
6. Palacios G. La codificación Axial, innovación metodológica. RECIE. Revista Electrónica Científicade Investigación EducativaVol. 3, núm. 1, enero-diciembre 2016, pp. 497-509. https://mail.rediech.org/ojs/2017/index.php/recie/article/view/244/325
7. Gamero, A. R. M., Chamorro, M. E. R., Molina, J. M. P., & Pacahuala, E. A. R. (2021). Burnout en los profesionales de la salud: ¿es un problema existente? Atención Primaria, 53(7), 102079. https://doi.org/10.1016/j.aprim.2021.102079
8. Servicios sanitarios de calidad. (s.f.). World Health Organization (WHO). https://www.who.int/es/news-room/fact-sheets/detail/quality-health-services
9. Tobar, F (2000). “Herramientas para el análisis del sector salud”. Medicina y Sociedad. volumen 23 número 2. Septiembre. https://filadd.com//doc/analisis-del-sector-salud-tobar-pdf-salud-publica
10. Belloni, A., D. Morgan and V. Paris (2016), “Pharmaceutical Expenditure And Policies: Past Trends And Future Challenges”, OECD Health Working Papers, No. 87, OECD Publishing, Paris, https://doi.org/10.1787/5jm0q1f4cdq7-en
11. Fasseeh, A., ElEzbawy, B., Adly, W., ElShahawy, R., George, M., Abaza, S., ElShalakani, A., & Kaló, Z. (2022). Healthcare financing in Egypt: a systematic literature review. Journal of the Egyptian Public Health Association, 97(1). https://doi.org/10.1186/s42506-021-00089-8
12. Wilson, A., & Childs, S. (2006, November 11). The effect of interventions to alter the consultation length of family physicians: a systematic review. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1927097/
13. Wilson, A. D., Childs, S., Gonçalves-Bradley, D. C., & Irving, G. J. (2016). Interventions to increase or decrease the length of primary care physicians’ consultation. Cochrane Library, 2016(8). https://doi.org/10.1002/14651858.cd003540.pub3
14. Löffler, C., & Böhmer, F. (2017). The effect of interventions aiming to optimise the prescription of antibiotics in dental care—A systematic review. PLoS ONE, 12(11), e0188061. https://doi.org/10.1371/journal.pone.0188061
15. Teni, F. S., Wubishet, B. L., & Yimenu, D. K. (2022). Systematic review and meta-analysis of medicine use studies in Ethiopia using the WHO patient care indicators with an emphasis on the availability of prescribed medicines. BMJ Open, 12(3), e054521. https://doi.org/10.1136/bmjopen-2021-054521
16. Gemmill, M. C., Thomson, S., & Mossialos, E. (2008). What impact do prescription drug charges have on efficiency and equity? Evidence from high-income countries. International Journal for Equity in Health, 7(1). https://doi.org/10.1186/1475-9276-7-12
17. Simou, E., & Koutsogeorgou, E. (2014). Effects of the economic crisis on health and healthcare in Greece in the literature from 2009 to 2013: A systematic review. Health Policy, 115(2–3), 111–119. https://doi.org/10.1016/j.healthpol.2014.02.002
18. Smith KA, Cipriani A, Geddes JR. The usefulness and interpretation of systematic reviews. BJPsych Adv. 2016;22(2):132–41. doi:10.1192/apt.bp.114.013128
19. Strauss A, Corbin J. Basics of Qualitative Research: Techniques and Procedures for Developing Grounded Theory. 2nd ed. Thousand Oaks: Sage Publications; 1998. p. 203-210. https://research-proposal.ir/wp-content/uploads/2019/06/Basics_of_Qualitative_Research__Techniques_and_Procedures_for_Developing_Grounded_Theory.pdf
20. Carter N, Bryant-Lukosius D, DiCenso A, Blythe J, Neville AJ. The use of triangulation in qualitative research. Oncol Nurs Forum. 2014;41(5):545–7. https://doi.org/10.1188/14.ONF.545-547
21. Acuña Gómez JS, Jiménez-Barbosa WG, Hernández Monsalve JS. Analysis of the feasibility of universal basic income in Colombia: a grounded theory study. Qual Rep. 2023;28(11):3272–300. doi:10.46743/2160-3715/2023.6123
22. Lublóy, Á. (2014). Factors affecting the uptake of new medicines: a systematic literature review. BMC Health Services Research, 14(1). https://doi.org/10.1186/1472-6963-14-469
23. Ofori-Asenso, R., Brhlikova, P., & Pollock, A. M. (2016). Prescribing indicators at primary health care centers within the WHO African region: a systematic analysis (1995–2015). BMC Public Health, 16(1). https://doi.org/10.1186/s12889-016-3428-8
24. Herrera, C. A., Lewin, S., Paulsen, E., Ciapponi, A., Opiyo, N., Pantoja, T., Rada, G., Wiysonge, C. S., Bastías, G., Marti, S. G., Okwundu, C. I., Peñaloza, B., & Oxman, A. D. (2017). Governance arrangements for health systems in low-income countries: an overview of systematic reviews. CochraneLibrary, 2017(9). https://doi.org/10.1002/14651858.cd011085.pub2
25. Lee, K. S., Kassab, Y. W., Taha, N. A., & Zainal, Z. A. (2021). A systematic review of pharmaceutical price mark-up practice and its implementation. Exploratory Research in Clinical and Social Pharmacy, 2, 100020. https://doi.org/10.1016/j.rcsop.2021.100020
26. Otieno, P. A., Campbell, S., Maley, S., Arunga, T. O., & Okumu, M. O. (2022). A Systematic Review of Pharmacist-Led antimicrobial stewardship programs in Sub-Saharan Africa. International Journal of Clinical Practice, 2022, 1–16. https://doi.org/10.1155/2022/3639943
27. Smith, S. M., Wallace, E., O’Dowd, T., & Fortin, M. (2016). Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Library. https://doi.org/10.1002/14651858.cd006560.pub3
28. Chamberlain, C., Owen-Smith, A., Donovan, J., & Hollingworth, W. (2015). A systematic review of geographical variation in access to chemotherapy. BMC Cancer, 16(1). https://doi.org/10.1186/s12885-015-2026-y
29. Nguyen, O. T., Tabriz, A. A., Huo, J., Hanna, K., Shea, C. M., & Turner, K. (2021). Impact of Asynchronous Electronic Communication–Based Visits on Clinical Outcomes and Health care Delivery: Systematic review. Journal of Medical Internet Research, 23(5), e27531. https://doi.org/10.2196/27531
30. Pantoja, T., Peñaloza, B., Cid, C., Herrera, C. A., Ramsay, C. R., & Hudson, J. (2022). Pharmaceutical policies: effects of regulating drug insurance schemes. Cochrane Library, 2022(5). https://doi.org/10.1002/14651858.cd011703.pub2
31. Green, C. J., Maclure, M., Fortin, P. M., Ramsay, C. R., Aaserud, M., & Bardal, S. (2010). Pharmaceutical policies: effects of restrictions on reimbursement. Cochrane Library. https://doi.org/10.1002/14651858.cd008654
32. Lee, I., Bloor, K., Hewitt, C., & Maynard, A. (2014). International experience in controlling pharmaceutical expenditure: influencing patients and providers and regulating industry – a systematic review. Journal of Health Services Research & Policy, 20(1), 52–59. https://doi.org/10.1177/1355819614545675
33. Bagheri Lankaran K, Khankeh H R, Zarei N, Fararouei M, Saboori Z, Joulaei H. Toward Equity under Health System Reform; A Systematic Review. Shiraz E-Med J. 2017;18(11):e57724. https://doi.org/10.5812/semj.57724
34. Zara Yahni, C., Segú Tolsa, L., Font Pous, M., & Rovira, J. (1998). La regulación de los medicamentos: teoría y práctica. Gaceta Sanitaria, 12(1), 39–49. https://doi.org/10.1016/s0213-9111(98)76441-6
35. Zahroh, R. I., Hazfiarini, A., Ed4dy, K. E., Vogel, J. P., Tunçalp, Ӧ., Minckas, N., Althabe, F., Oladapo, O. T., & Bohren, M. A. (2022). Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative synthesis. PLoS Medicine, 19(8), e1004074. https://doi.org/10.1371/journal.pmed.1004074
36. Nasr, Z., Paravattil, B., & Wilby, K. (2017). the impact of antimicrobial stewardship strategies on antibiotic appropriateness and prescribing behaviours in selected countries in the Middle East: a systematic review. Eastern Mediterranean Health Journal, 23(6), 430–440. https://doi.org/10.26719/217.23.6.430
37. Soares MA, Fernandez-Llimos F, Cabrita J, Morais J. (2011). Tools to evaluate potentially inappropriate prescription in the elderly- A Systematic Review. Acta Medica Portuguesa. 2011; 24(5):775-784. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/509/217
38. Kheirandish, M., Rashidian, A., Kebriaeezade, A., Cheraghali, A. M., & Soleymani, F. (2015). A review of pharmaceutical policies in response to economic crises and sanctions. Journal of research in pharmacy practice, 4(3), 115–122. https://doi.org/10.4103/2279-042X.162361
39. Newman M., Bangpan M., Kalra M., Mays N., Kwan I., Robert T. (2012) Commissioning in health, education and social care: Models, research bibliography and in-depth review of joint commissioning between health and social care agencies. (n.d.). https://eppi.ioe.ac.uk/cms/Default.aspx?tabid=3356
40. Puig-Junoy, J., & Moreno-Torres, I. (2007). Impact of pharmaceutical prior authorisation policies. PharmacoEconomics, 25(8), 637–648. https://doi.org/10.2165/00019053-200725080-00002
41. Doshi, J. A., PhD, Li, P., PhD, Bs, V. P. L., Pettit, A. R., PhD, & Msph, E. a. T. P. (2020, August 6). Impact of cost sharing on specialty drug utilization and Outcomes: A review of the evidence and future directions. AJMC. https://www.ajmc.com/view/impact-ofcost-sharing-on-specialty-drug-utilization-and-outcomes-a-review-of-the-evidence-and-future-directions
42. Joosse, I. R., Tordrup, D., Glanville, J., Kotas, E., Mantel-Teeuwisse, A. K., & Van Den Ham, H. A. (2023). Evidence on the effectiveness of policies promoting price transparency - A systematic review. Health Policy, 134, 104681. https://doi.org/10.1016/j.healthpol.2022.11.002
43. Schlander, M., Dintsios, C., & Gandjour, A. (2018). Budgetary impact and cost drivers of drugs for rare and ultrarare diseases. Value in Health, 21(5), 525–531. https://doi.org/10.1016/j.jval.2017.10.015
44. Lin, L., Sun, R., Yao, T., Zhou, X., & Harbarth, S. (2020). Factors influencing inappropriate use of antibiotics in outpatient and community settings in China: a mixed-methods systematic review. BMJ Global Health, 5(11), e003599. https://doi.org/10.1136/bmjgh-2020-003599
45. Lim, J. M., Singh, S. R., Duong, M. C., Legido-Quigley, H., Hsu, L. Y., & Tam, C. C. (2019). Impact of national interventions to promote responsible antibiotic use: a systematic review. Journal of Antimicrobial Chemotherapy, 75(1), 14–29. https://doi.org/10.1093/jac/dkz348
46. Coope, C., Schneider, A., Zhang, T., Kadetz, P., Feng, R., Lambert, H., Wang, D., Oliver, I., Michie, S., & Cabral, C. (2022). Identifying key influences on antibiotic use in China: a systematic scoping review and narrative synthesis. BMJ Open, 12(3), e056348. https://doi.org/10.1136/bmjopen-2021-56348
47. Smith, S. M., Wallace, E., O’Dowd, T., & Fortin, M. (2021). Interventions for improving outcomes in patients with multimorbidity in primary care and community settings. Cochrane Library, 2021(5). https://doi.org/10.1002/14651858.cd006560.pub4
48. Zahroh, R. 8I., Hazfiarini, A., Eddy, K. E., Vogel, J. P., Tunçalp, Ӧ., Minckas, N., Althabe, F., Oladapo, O. T., & Bohren, M. A. (2022). Factors influencing appropriate use of interventions for management of women experiencing preterm birth: A mixed-methods systematic review and narrative synthesis. PLoS Medicine, 19(8), e1004074. https://doi.org/10.1371/journal.pmed.1004074
49. Koli, P. G., Kshirsagar, N. A., Shetty, Y. C., Mehta, D., Mittal, Y., & Parmar, U. (2019). A systematic review of standard treatment guidelines in India. The Indian Journal of Medical Research, 149(6), 715. https://doi.org/10.4103/ijmr.ijmr_902_17
50. Bighelli, I., Ostuzzi, G., Girlanda, F., Cipriani, A., Becker, T., Koesters, M., & Barbui, C. (2016). Implementation of treatment guidelines for specialist mental health care. Cochrane Library, 2016(12). https://doi.org/10.1002/14651858.cd009780.pub3
51. Haegerich, T. M., Jones, C. M., Cote, P., Robinson, A., & Ross, L. (2019). Evidence for state, community and systems-level prevention strategies to address the opioid crisis. Drug and Alcohol Dependence, 204, 107563. https://doi.org/10.1016/j.drugalcdep.2019.107563
52. Lee, H., Choi, H. S., & Ji, E. (2019). The Effects after Implementing a Drug Utilization Review System on Contraindicated Drug use: A Systematic Review. Korean Journal of Clinical Pharmacy, 29(1), 9–17. https://doi.org/10.24304/kjcp.2019.29.1.9
53. Puac-Polanco, V., Chihuri, S., Fink, D. S., Cerdá, M., Keyes, K. M., & Li, G. (2020). Prescription drug monitoring programs and Prescription Opioid–Related Outcomes in the United States. Epidemiologic Reviews, 42(1), 134–153. https://doi.org/10.1093/epirev/mxaa002
54. Ross, S., & Loke, Y. K. (2010). Development of learning outcomes for an undergraduate prescribing curriculum (British Pharmacological Society prescribing initiative). British Journal of Clinical Pharmacology, 70(4), 604–608. https://doi.org/10.1111/j.1365-2125.2009.03581.x
55. Ahmed, Z., Barber, N., Jani, Y., Garfield, S., & Franklin, B. D. (2016). Economic impact of electronic prescribing in the hospital setting: A systematic review. International Journal of Medical Informatics, 88, 1–7. https://doi.org/10.1016/j.ijmedinf.2015.11.008
56. Mohsin-Shaikh, S., Furniss, D., Blandford, A., McLeod, M., Ma, T., Beykloo, M. Y., & Franklin, B. D. (2019). The impact of electronic prescribing systems on healthcare professionals’ working practices in the hospital setting: a systematic review and narrative synthesis. BMC Health Services Research,19(1). https://doi.org/10.1186/s12913-019-4554-7
57. Radley, D. C., Wasserman, M. R., Olsho, L. E., Shoemaker, S. J., Spranca, M. D., & Bradshaw, B. (2013). Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems. Journal of the American Medical Informatics Association, 20(3), 470–476. https://doi.org/10.1136/amiajnl-2012-001241
58. Okamoto, E. (2008). Do individualized health promotional programs reduce health care expenditure? A systematic review of controlled trials in the “Health-Up” model projects of the National Health Insurance. PubMed. https://pubmed.ncbi.nlm.nih.gov/19227923/
59. Williams, J., Malden, S., Heeney, C., Bouamrane, M., Holder, M., Perera, U., Bates, D. W., & Sheikh, A. (2022). Optimizing Hospital Electronic Prescribing Systems: A Systematic Scoping review. Journal of Patient Safety, 18(2), e547–e562. https://doi.org/10.1097/pts.0000000000000867
60. Milosavljevic, A., Aspden, T., & Harrison, J. (2018). Community pharmacist-led interventions and their impact on patients’ medication adherence and other health outcomes: a systematic review. International Journal of Pharmacy Practice, 26(5), 387–397. https://doi.org/10.1111/ijpp.12462
61. Raban, M. Z., Gonzalez, G., Nguyen, A. D., Newell, B. R., Li, L., Seaman, K. L., & Westbrook, J. I. (2023). Nudge interventions to reduce unnecessary antibiotic prescribing in primary care: a systematic review. BMJ Open, 13(1), e062688. https://doi.org/10.1136/bmjopen-2022-062688#
62. Mortazhejri, S., Hong, P. J., Yu, A. M., Hong, B. Y., Stacey, D., Bhatia, R. S., & Grimshaw, J. M. (2020). Systematic review of patient-oriented interventions to reduce unnecessary use of antibiotics for upper respiratory tract infections. Systematic reviews, 9(1), 106. https://doi.org/10.1186/s13643-020-01359-w
63. Feather, C., Appelbaum, N., Darzi, A., & Franklin, B. D. (2023). Indication documentation and indication-based prescribing within electronic prescribing systems: a systematic review and narrative synthesis. BMJ Quality & Safety, 32(6), 357–368. https://doi.org/10.1136/bmjqs-2022-015452
64. Acosta, A., Ciapponi, A., Aaserud, M., Vietto, V., Austvoll-Dahlgren, A., Kösters, J. P., Vacca, C., Machado, M., Ayala, D. H. D., & Oxman, A. D. (2014). Pharmaceutical policies: effects of reference pricing, other pricing, and purchasing policies. Cochrane Library, 2019(8). https://doi.org/10.1002/14651858.cd005979.pub2
65. Gemmill, M. C., Thomson, S., & Mossialos, E. (2008). What impact do prescription drug charges have on efficiency and equity? Evidence from high-income countries. International Journal for Equity in Health, 7(1). https://doi.org/10.1186/1475-9276-7-12
66. Preckler, V., & Espín, J. (2022). The Role of Indication-Based Pricing in Future Pricing and Reimbursement Policies: A Systematic review. Value in Health, 25(4), 666–675. https://doi.org/10.1016/j.jval.2021.11.1376
67. Rashidian, A., Omidvari, A., Vali, Y., Sturm, H., & Oxman, A. D. (2015). Pharmaceutical policies: effects of financial incentives for prescribers. Cochrane Library, 2015(8). https://doi.org/10.1002/14651858.cd006731.pub2
68. Luiza, V. L., Chaves, L. A., Silva, R. M., Emmerick, I. C. M., Chaves, G. C., De Araújo, S. C. F., Moraes, E. L., & Oxman, A. D. (2015). Pharmaceutical policies: effects of cap and co-payment on rational use of medicines. Cochrane Library, 2015(5). https://doi.org/10.1002/14651858.cd007017.pub2
69. Wang, S. Y., & Groene, O. (2020). The effectiveness of behavioral economics-informed interventions on physician behavioral change: A systematic literature review. PLoS ONE, 15(6), e0234149. https://doi.org/10.1371/journal.pone.0234149
70. Beaudoin, F. L., Banerjee, G. N., & Mello, M. J. (2016). State-level and system-level opioid prescribing policies: The impact on provider practices and overdose deaths, a systematic review. Journal of Opioid Management, 12(2), 109–118. https://doi.org/10.5055/jom.2016.0322
71. Fickweiler, F., Fickweiler, W., & Urbach, E. (2017). Interactions between physicians and the pharmaceutical industry generally and sales representatives specifically and their association with physicians’ attitudes and prescribing habits: a systematic review. BMJ Open, 7(9), e016408. https://doi.org/10.1136/bmjopen-2017-016408
72. Fadlallah, R., Nas, H., Naamani, D., El-Jardali, F., Hammoura, I., Al-Khaled, L., Brax, H., Kahale, L., & Akl, E. A. (2016). Knowledge, Beliefs and Attitudes of Patients and the General Public towards the Interactions of Physicians with the Pharmaceutical and the Device Industry: A Systematic Review. PLoS ONE, 11(8), e0160540. https://doi.org/10.1371/journal.pone.0160540
73. Hawkins, O., Scott, A. M., Montgomery, A., Nicholas, B., Mullan, J., van Oijen, A., & Degeling, C. (2022). Comparing public attitudes, knowledge, beliefs and behaviours towards antibiotics and antimicrobial resistance in Australia, United Kingdom, and Sweden (2010-2021): A systematic review, meta-analysis, and comparative policy analysis. PloS one, 17(1), e0261917. https://doi.org/10.1371/journal.pone.0261917
74. Stadhouders, N., Kruse, F., Tanke, M., Koolman, X., & Jeurissen, P. (2019). Effective healthcare cost-containment policies: A systematic review. Health Policy, 123(1), 71–79. https://doi.org/10.1016/j.healthpol.2018.10.015
75. Sinnott, S., Buckley, C., O′Riordan, D., Bradley, C., & Whelton, H. (2013). The effect of copayments for prescriptions on adherence to prescription medicines in publicly insured populations; A Systematic Review and Meta-Analysis. PLoS ONE, 8(5), e64914. https://doi.org/10.1371/journal.pone.0064914
76. Mitchell, A. P., Trivedi, N. U., Gennarelli, R. L., Chimonas, S., Tabatabai, S. M., Goldberg, J., Diaz, L. A., & Korenstein, D. (2021). Are financial payments from the pharmaceutical industry associated with physician prescribing? Annals of Internal Medicine, 174(3), 353–361. https://doi.org/10.7326/m20-5665
77. Guo, S., Sun, Q., Zhao, X., Shen, L., & Zhen, X. (2021). Prevalence and risk factors for antibiotic utilization in Chinese children. BMC Pediatrics, 21(1). https://doi.org/10.1186/s12887-021-02706-z
78. Thanimalai, S., Choon, W. Y., & Lee, K. K. (2021). Stakeholder views of managed entry agreements: A literature review of national studies. Health Policy OPEN, 2, 100032. https://doi.org/10.1016/j.hpopen.2021.100032
79. Jia, L., Meng, Q., Scott, A., Yuan, B., & Zhang, L. (2021). Payment methods for healthcare providers working in outpatient healthcare settings. Cochrane Library, 2021(1). https://doi.org/10.1002/14651858.cd011865.pub2
80. Seidman, G., & Atun, R. (2017). Do changes to supply chains and procurement processes yield cost savings and improve availability of pharmaceuticals, vaccines or health products? A systematic review of evidence from low-income and middleincome countries. BMJ Global Health, 2(2), e000243. https://doi.org/10.1136/bmjgh-2016-000243
81. Puig-Junoy J. (2010). Políticas de fomento de la competencia en precios en el mercado de genéricos: lecciones de la experiencia europea [Policies encouraging price competition in the generic drug market: Lessons from the European experience]. Gaceta sanitaria, 24(3), 193–199. https://doi.org/10.116/j.gaceta.2009.12.003
82. Moe-Byrne, T., Chambers, D., Harden, M., & McDaid, C. (2014). Behaviour change interventions to promote prescribing of generic drugs: a rapid evidence synthesis and systematic review. BMJ Open, 4(5), e004623. https://doi.org/10.1136/bmjopen-2013-004623
83. Flodgren, G., Gonçalves-Bradley, D. C., & Pomey, M. (2016). External inspection of compliance with standards for improved healthcare outcomes. Cochrane Library, 2016(12). https://doi.org/10.1002/14651858.cd008992.pub3
84. McKay, R., Mah, A., Law, M. R., McGrail, K., & Patrick, D. M. (2016). Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections. Antimicrobial Agents and Chemotherapy, 60(7), 4106–4118. https://doi.org/10.1128/aac.00209-16
85. Hodkinson, A., Tyler, N., Ashcroft, D. M., Keers, R. N., Khan, K., Phipps, D., Abuzour, A., Bower, P., Avery, A., Campbell, S., & Panagioti, M. (2020). Preventable medication harm across health care settings: a systematic review and meta-analysis. BMC Medicine, 18(1). https://doi.org/10.1186/s129-16020-01774-9
86. Rosner, B., Neicun, J., Yang, J. C., & Roman-Urrestarazu, A. (2019). Opioid prescription patterns in Germany and the global opioid epidemic: Systematic review of available evidence. PLoS ONE, 14(8), e0221153. https://doi.org/10.1371/journal.pone.0221153
87. De Oliveira Costa, J., Bruno, C., Schaffer, A. L., Raichand, S., Karanges, E. A., & Pearson, S. (2021). The changing face of Australian data reforms: Impact on pharmacoepidemiology research. International Journal for Population Data Science, 6(1). https://doi.org/10.23889/ijpds.v6i1.1418
88. Teixeira Rodrigues, A., Roque, F., Falcão, A., Figueiras, A., & Herdeiro, M. T. (2013). Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies. International Journal of Antimicrobial Agents, 41(3), 203–212. https://doi.org/10.1016/j.ijantimicag.2012.09.03
89. Belachew, S. A., Hall, L., & Selvey, L. A. (2021). Non-prescription dispensing of antibiotic agents among community drug retail outlets in Sub-Saharan African countries: a systematic review and meta-analysis. Antimicrobial Resistance and Infection Control, 10(1). https://doi.org/10.1186/s13756-020-00880-w
90. Zerah, L., Bun, R., Guillo, S., Collet, J., Bonnet-Zamponi, D., & Tubach, F. (2019). A prescription support-tool for chronic management of oral antithrombotic combinations in adults based on a systematic review of international guidelines. PLoS ONE, 14(2), e0211695. https://doi.org/10.1371/journal.pone.0211695
91. Leon, N., Balakrishna, Y., Hohlfeld, A., Odendaal, W. A., Schmidt, B., Zweigenthal, V., Watkins, J. A., & Daniels, K. (2020). Routine Health Information System (RHIS) improvements for strengthened health system management. Cochrane Library, 2020(8). https://doi.org/10.1002/14651858.cd012012.pub2
92. Austad, K. E., Avorn, J., & Kesselheim, A. S. (2011). Medical Students’ Exposure to and Attitudes about the Pharmaceutical Industry: A Systematic Review. PLoS Medicine, 8(5), e1001037. https://doi.org/10.1371/journal.pmed.1001037
93. Helou, R. I., Foudraine, D. E., Catho, G., Latif, A. P., Verkaik, N. J., & Verbon, A. (2020). Use of stewardship smartphone applications by physicians and prescribing of antimicrobials in hospitals: A systematic review. PLoS ONE, 15(9), e0239751. https://doi.org/10.1371/journal.pone.0239751
94. Morelli SG, Sapede M, Silva ATC. Burnout em médicos da Atenção Primária: uma revisão sistemática. Rev Bras Med Fam Comunidade. 2015;10(34):1-9. http://dx.doi.org/105712/rbmfc10(34)95
95. Andrews, T., Thompson, M., Buckley, D. I., Heneghan, C., Deyo, R., Redmond, N., Lucas, P. J., Blair, P. S., & Hay, A. D. (2012). Interventions to Influence Consulting and Antibiotic Use for Acute Respiratory Tract Infections in Children: A Systematic Review and Meta-Analysis. PLoS ONE, 7(1), e30334. https://doi.org/10.1371/journal.pone.0030334
96. Evrard, P., Pétein, C., Beuscart, J., & Spinewine, A. (2022). Barriers and enablers for deprescribing benzodiazepine receptor agonists in older adults: a systematic review of qualitative and quantitative studies using the theoretical domains framework. Implementation Science, 17(1). https://doi.org/10.1186/s13012-022-01206-7
97. Squires, J. E., Cho-Young, D., Aloisio, L. D., Bell, R., Bornstein, S., Brien, S. E., Decary, S., Varin, M. D., Dobrow, M., Estabrooks, C. A., Graham, I. D., Greenough, M., Grinspun, D., Hillmer, M., Horsley, T., Hu, J., Katz, A., Krause, C., Lavis, J., . . . Grimshaw, J. M. (2022). Inappropriateuse of clinical practices in Canada: a systematic review. Canadian Medical Association Journal, 194(8), E279–E296. https://doi.org/10.1503/cmaj.211416
98. Hatef, E., Wilson, R. F., Hannum, S. M., Zhang, A., Kharrazi, H., Weiner, J. P., Davis, S. A., & Robinson, K. A. (2023). Use of telehealth during the COVID-19 era. https://doi.org/10.23970/ahrqepcsrcovidtelehealth
99. Bhanbhro, S., Drennan, V. M., Grant, R., & Harris, R. (2011). Assessing the contribution of prescribing in primary care by nurses and professionals allied to medicine: a systematic review of literature. BMC Health Services Research, 11(1). https://doi.org/10.1186/1472-6963-11-330
100. Salamanca-Buentello, F., Cheng, D. K., Sabioni, P., Majid, U., Upshur, R., & Sud, A. (2022). Mal/adaptations: A qualitative evidence synthesis of opioid agonist therapy during major disruptions. International Journal of Drug Policy, 101, 103556. https://doi.org/10.1016/j.drugpo.2021.103556
101. Lucas, P. J., Cabral, C., Hay, A. D., & Horwood, J. (2015). A systematic review of parent and clinician views and perceptions that influence prescribing decisions in relation to acute childhood infections in primary care. Scandinavian Journal of Primary Health Care, 33(1), 11–20. https://doi.org/10.3109/02813432.2015.1001942
102. Bednarczyk, E., Cook, S., Brauer, R., & Garfield, S. (2022). Stakeholders’ views on the use of psychotropic medication in older people: a systematic review. Age And Ageing, 51(3). https://doi.org/10.1093/ageing/afac060
103. Wu, S., Tannous, E., Haldane, V., Ellen, M. E., & Wei, X. (2022). Barriers and facilitators of implementing interventions to improve appropriate antibiotic use in low- and middle-income countries: a systematic review based on the Consolidated Framework for Implementation Research. ImplementationScience, 17(1). https://doi.org/10.1186/s13012-022-01209-4
104. Pantoja, T., Opiyo, N., Lewin, S., Paulsen, E., Ciapponi, A., Wiysonge, C. S., Herrera, C. A., Rada, G., Peñaloza, B., Dudley, L., Gagnon, M., Marti, S. G., & Oxman, A. D. (2017). Implementation strategies for health systems in low-income countries: an overview of systematic reviews. Cochrane Library,2017(9). https://doi.org/10.1002/14651858.cd011086.pub2
105. Daoust, R., Paquet, J., Marquis, M., Chauny, J., Williamson, D., Huard, V., Arbour, C., Émond, M., & Cournoyer, A. (2022). Evaluation of interventions to reduce opioid prescribing for patients discharged from the emergency department. JAMA Network Open, 5(1), e2143425. https://doi.org/10.1001/jamanetworkopen.2021.43425
106. DeFrank, J. T., Berkman, N. D., Kahwati, L., Cullen, K., Aikin, K. J., & Sullivan, H. W. (2019). Direct-to-Consumer Advertising of Prescription Drugs and the Patient–Prescriber Encounter: A Systematic review. Health Communication, 35(6), 739–746. https://doi.org/10.1080/10410236.2019.1584781
107. Grundy, Q., Bero, L., & Malone, R. (2013). Interactions between Non-Physician Clinicians and Industry: A Systematic Review. PLoS Medicine, 10(11), e1001561. https://doi.org/10.1371/journal.pmed.1001561
108. M’Imunya, J. M., Kredo, T., & Volmink, J. (2012). Patient education and counselling for promoting adherence to treatment for tuberculosis. Cochrane Library. https://doi.org/10.1002/14651858.cd006591.pub2
109. Horne, R., Chapman, S. C. E., Parham, R., Freemantle, N., Forbes, A., & Cooper, V. (2013). Understanding Patients’ Adherence-Related Beliefs about Medicines Prescribed for Long-Term Conditions: A Meta-Analytic Review of the Necessity-Concerns Framework. PLoS ONE, 8(12), e80633. https://doi.org/10.1371/journal.pone.0080633
110. Anderson, L. J., Nuckols, T. K., Coles, C., Le, M. M., Schnipper, J. L., Shane, R., Jackevicius, C., Lee, J., Pevnick, J. M., Choudhry, N. K., O’Mahony, D., & Sarkisian, C. (2020). A systematic overview of systematic reviews evaluating medication adherence interventions. American Journal of Health-System Pharmacy, 77(2), 138–147. https://doi.org/10.1093/ajhp/zxz284
111. Islam, M. D., Kaplan, W. A., Trachtenberg, D., Thrasher, R., Gallagher, K. P., & Wirtz, V. J. (2019). Impacts of intellectual property provisions in trade treaties on access to medicine in low and middle income countries: a systematic review. Globalization and Health, 15(1). https://doi.org/10.1186/s12992-019-0528-0
112. Schirle, L., Stone, A. L., Morris, M. C., Osmundson, S. S., Walker, P. D., Dietrich, M. S., & Bruehl, S. (2020). Leftover opioids following adult surgical procedures: a systematic review and meta-analysis. Systematic Reviews, 9(1). https://doi.org/10.1186/s13643-020-01393-8
113. Shojania, K. G., Jennings, A., Ramsay, C. R., Grimshaw, J. M., Kwan, J. L., & Lo, L. (2009). The effects of on-screen, point of care computer reminders on processes and outcomes of care. Cochrane Library, 2021(6). https://doi.org/10.1002/14651858.cd001096.pub2
114. Saulle, R., Vecchi, S., & Gowing, L. (2017). Supervised dosing with a long-acting opioid medication in the management of opioid dependence. Cochrane Library, 2017(4). https://doi.org/10.1002/14651858.cd011983.pub2
115. Suleman, F., & Movik, E. (2019). Pharmaceutical policies: effects of educational or regulatory policies targeting prescribers. Cochrane Library, 2019(11). https://doi.org/10.1002/14651858.cd013478
116. Papadakos, J. K., Hasan, S. M., Barnsley, J., Berta, W., Fazelzad, R., Papadakos, C. J., Giuliani, M. E., & Howell, D. (2018). Health literacy and cancer self‐management behaviors: A scoping review. Cancer, 124(21), 4202–4210. https://doi.org/10.1002/cncr.31733
117. Wiysonge, C. S., Abdullahi, L. H., Ndze, V. N., & Hussey, G. D. (2016). Public stewardship of private for-profit healthcare providers in low- and middle-income countries. Cochrane Library, 2016(9). https://doi.org/10.1002/14651858.cd009855.pub2
118. Sachidanandan, G., Bechard, L. E., Hodgson, K., & Sud, A. (2022). Education as drug policy: A realist synthesis of continuing professional development for opioid agonist therapy. International Journal of Drug Policy, 108, 103807. https://doi.org/10.1016/j.drugpo.2022.103807
