Bridging the gap: dental interventions for improved glycemic control in diabetic patients: A systematic review of published studies
Main Article Content
Keywords
Dental, Glycemic Control, Diabetic, Oral Health, care management
Abstract
Background: Diabetes poses an increased risk for oral health complications like periodontal disease and candidiasis. Proper dental management can help reduce these risks and support medical glycemic control. Methods: A systematic search of 5 databases was conducted from 2013 to 2023. Included studies evaluated interventions or assessed relationships between dental care and diabetes outcomes. Two reviewers independently screened titles/ abstracts and full-texts, extracted data, and assessed risk of bias. Results: An initial search found 895 records, of which 48 were duplicates and 79 were excluded after title/abstract screening. 284 studies underwent full-text review, with 145 excluded for not meeting criteria. 10 studies ultimately met all inclusion criteria. Current evidence establishes periodontitis as a risk factor for worsening diabetes and complications. Periodontal therapy helps manage glycemic control and is most effective with intensive follow-up support. Diabetes increases oral candidiasis risk. Maintaining optimal blood glucose levels reduces periodontal disease prevalence. Conclusion: Current evidence indicates periodontal therapy positively impacts glycemic control in diabetics and intensive follow-up may maximize benefits. Diabetes increases susceptibility to oral candidiasis. Curricula changes equip future dentists to coordinate care considering patients’ medical needs
References
2. Zhou B, Lu Y, Hajifathalian K, Bentham J, Di Cesare M, Ezzati M, et al. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387(10027):1513-30.
3. Rowley WR, Bezold C, Arikan Y, Byrne E, Krohe S. Diabetes 2030: insights from yesterday, today, and future trends. Popul Health Manag. 2017;20(1):6-12.
4. Alotaibi A, Perry L, Gholizadeh L, Al-Ganmi A. Incidence and prevalence rates of diabetes mellitus in Saudi Arabia: An overview. J Epidemiol Glob Health. 2017;7(4):211-8.
5. Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017;376(15):1419-29.
6. Syed FZ. Type 1 diabetes mellitus. Ann Intern Med. 2022;175(5):ITC33-ITC48.
7. Ayani NKD, Juniartha IGN, Widyanthari DM. The Correlation between Body Mass Index (BMI) and Salivary pH on Type 2 Diabetes Mellitus Patients in Work Area of Health Center III North Denpasar. J Sustain Glob South. 2022;6:1.
8. Griffin TP, O’Loughlin A, Dinneen SF. How Should Secondary Causes of Diabetes Be Excluded? In: Clinical Dilemmas in Diabetes. 2021. p. 45-67.
9. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nat Rev Dis Primers. 2019;5:47.
10. Inzucchi SE. Diagnosis of diabetes. N Engl J Med. 2012;367(6):542-50.
11. Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol. 2020;16(7):377-90.
12. Harding JL, Pavkov ME, Magliano DJ, Shaw JE, Gregg EW. Global trends in diabetes complications: a review of current evidence.
Diabetologia. 2019;62(1):3-16.
13. Ravindran R, Deepa M, Sruthi A, Kuruvila C, Priya S, Sunil S, et al. Evaluation of Oral Health in Type II Diabetes Mellitus Patients.
Oral Maxillofac Pathol J. 2015;6(1).
14. Pearson-Stuttard J, Blundell S, Harris T, Cook DG, Critchley J. Diabetes and infection: assessing the association with glycaemic
control in population-based studies. Lancet Diabetes Endocrinol. 2016;4(2):148-58.
15. Wu YY, Xiao E, Graves DT. Diabetes mellitus related bone metabolism and periodontal disease. Int J Oral Sci. 2015;7(2):63-72.
16. Nazir MA, Alghamdi L, Alkadi M, Albeajan N, Alrashoudi L, Alhussan M. The burden of diabetes, its oral complications and their prevention and management. Open Access Maced J Med Sci. 2018;6(9):1545.
17. Polak D, Sanui T, Nishimura F, Shapira L. Diabetes as a risk factor for periodontal disease—plausible mechanisms. Periodontol 2000. 2020;83:46-58.
18. Chen YF, Zhan Q, Wu CZ, Yuan YH, Chen W, Yu FY, et al. Baseline HbA1c level influences the effect of periodontal therapy on glycemic control in people with type 2 diabetes and periodontitis: a systematic review on randomized controlled trials. Diabetes Ther. 2021;12(5):1249-78.
19. Hayashi J, Hasegawa A, Hayashi K, Suzuki T, Ishii M, Otsuka H, et al. Effects of periodontal treatment on the medical status of patients with type 2 diabetes mellitus: a pilot study. BMC Oral Health. 2017;17(1):1-6.
20. Baeza M, Morales A, Cisterna C, Cavalla F, Jara G, Isamitt Y, et al. Effect of periodontal treatment in patients with periodontitis
and diabetes: systematic review and meta-analysis. J Appl Oral Sci. 2020;28:e20190248.
21. Radmand SS. Effect of non-surgical periodontal treatment on glycemic control and periodontal status in diabetes mellitus type 2 patient with chronic periodontitis. A systematic review. 2018.
22. Chambrone L, Wang HL, Romanos GE. Antimicrobial photodynamic therapy for the treatment of periodontitis and periimplantitis:
An American Academy of Periodontology best evidence review. J Periodontol. 2018;89(7):783-803.
23. Unniachan AS, Jayakumari NK, Sethuraman S. Association between Candida species and periodontal disease: A systematic
review. Curr Med Mycol. 2020;6(1):63.
24. Zomorodian K, Kavousi F, Pishdad GR, Mehriar P, Ebrahimi H, Bandegani A, et al. Prevalence of oral Candida colonization in patients with diabetes mellitus. J Mycol Med. 2016;26(2):103-10.
25. Vila T, Sultan AS, Montelongo-Jauregui D, Jabra-Rizk MA. Oral candidiasis: a disease of opportunity. J Fungi (Basel). 2020;6(1):15.
26. Al‐Nasser L, Lamster IB. Prevention and management of periodontal diseases and dental caries in the older adults. Periodontol 2000. 2020;84:69-83.
27. De Lima AKA, Amorim dos Santos J, Stefani CM, Almeida de Lima AD, Damé-Teixeira N. Diabetes mellitus and poor glycemic control increase the occurrence of coronal and root caries: a systematic review and meta-analysis. Clin Oral Investig. 2020;24(10):3801-12.
28. Ribeiro BA, Vieira Lima CP, Alves LS, Damé-Teixeira N. Impact of detection criteria on coronal and root caries estimates in adults
with and without type 2 diabetes mellitus. Clin Oral Investig. 2022;1-9.
29. Wade WG. Resilience of the oral microbiome. Periodontol 2000. 2021;86(1):113-22.
30. Atchison KA, Weintraub JA, Rozier RG. Bridging the dental-medical divide: Case studies integrating oral health care and primary health care. J Am Dent Assoc. 2018;149(10):850-8.
31. Preshaw PM, Bisset SM. Periodontitis and diabetes. Br Dent J. 2019;227(7):577-84.
32. Sundar C, Ramalingam S, Mohan V, Pradeepa R, Ramakrishnan MJ. Periodontal therapy as an adjunctive modality for HbA1c
reduction in type-2 diabetic patients. J Educ Health Promot. 2018;7:152.
33. Li Q, Hao S, Fang J, Xie J, Kong XH, Yang JX. Effect of non-surgical periodontal treatment on glycemic control of patients
with diabetes: a meta-analysis of randomized controlled trials. Trials. 2015;16:291 Kapoor A, Malhotra R, Grover V, Grover D.
Systemic antibiotic therapy in periodontics. Dent Res J (Isfahan). 2012;9(5):505-15.
34. Kapoor A, Malhotra R, Grover V, Grover D. Systemic antibiotic therapy in periodontics. Dent Res J (Isfahan). 2012;9(5):505-15.
35. Jain A, Gupta J, Bansal D, Sood S, Gupta S, Jain A. Effect of scaling and root planing as monotherapy on glycemic control
in patients of Type 2 diabetes with chronic periodontitis: A systematic review and meta-analysis. J Indian Soc Periodontol.
2019;23(4):303.
36. Rodrigues CF, Rodrigues ME, Henriques M. Candida sp. Infections in Patients with Diabetes Mellitus. J Clin Med. 2019;8(1):76.
37. Parakh MK, Ulaganambi S, Ashifa N, Premkumar R, Jain AL. Oral potentially malignant disorders: clinical diagnosis and current screening aids: a narrative review. Eur J Cancer Prev. 2020;29(1):65-72.
38. Coelho AS, Amaro IF, Caramelo F, Paula A, Marto CM, Ferreira MM, et al. Dental caries, diabetes mellitus, metabolic control and diabetes duration: A systematic review and meta‐analysis. J Esthet Restor Dent. 2020;32(3):291-309.
39. Kocher T, Holtfreter B, Petersmann A, Eickholz P, Hoffmann T, Kaner D, et al. Effect of periodontal treatment on HbA1c among patients with prediabetes. J Dent Res. 2019;98(2):171-9.
40. Genco RJ, Graziani F, Hasturk H. Effects of periodontal disease on glycemic control, complications, and incidence of diabetes mellitus. Periodontol 2000. 2020;83:59-65.