Assessment of Adherence to Medications and Prevalence of depression among hemodialysis patients
Main Article Content
Keywords
Glomerular filtration rate, Medication adherence, Patient compliance, Renal dialysis
Abstract
Background: End-stage kidney disease requires renal replacement therapy (RRT) because of a gradual decline in kidney function. Hemodialysis is the most commonly used renal replacement therapy worldwide, and frequently leads to neuropsychiatric issues, with depression being the most prominent. Nonadherence to drug therapy is considered one of the most significant drug-related issues among hemodialysis patients, and various studies have shown that nonadherence is common. This study aimed to determine the prevalence of depression and non-adherence to drug therapy, and to identify predictors of depression and non-adherence among hemodialysis patients. Subjects and Methods: This cross-sectional study included 99 patients and 33 healthy controls. The data collected encompassed personal and disease-related variables The data collected included personal and disease-related variables from AL-Yarmouk Hospital during the period from 20th July to 20 August 2019. Adherence to medication was assessed using a validated medication adherence scale and participants’ depression levels were evaluated using a standardized depression questionnaire. Results: The median age of the patients was 51.2 ± 14.4 years, with the majority being male (67.7%). Depression was prevalent in 86.9% of the patients, which was significantly higher than the prevalence in the control group (63.6%). The sick group’s median depression score was noticeably greater than the control groups. There were no discernible differences between patients with and without depression in terms of sociodemographic characteristics or illness indicators. Non-adherence was common, with 47.47% of the patients being non-adherent. Conclusions: Depression is prevalent among hemodialysis patients and is unrelated to any personal or medical features.
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4. Beshna E, Alwafi SA, Lazrak RR. Evaluation of the Quality of life of Zawia (Libya) patients undergoing hemodialysis. Medical and Pharmaceutical Journal. 2023 ;2(1):4-16. https://doi.org/10.55940/medphar202229
5. Humudat YR, Al-Naseri SK. Heavy metals in dialysis fluid and blood samples from hemodialysis patients in dialysis centers in baghdad, iraq. Journal of Health and Pollution. 2020;10(27):200901. https://doi.org/10.5696/2156-9614-10.27.200901
6. Al Attar B. Renal replacement therapy in the Kingdom of Saudi Arabia. Saudi Journal of Kidney Diseases and Transplantation. 2020;31(6):1458-69. https://doi.org/10.4103/1319-2442.308375
7. Shahbaz M. Data from a large hemodialysis center form an industrial city: Demographics, etiology and hepatitis status. Pakistan Journal of Kidney Diseases. 2019;3(10).
8. Wilkie M, Davies S. Peritoneal dialysis in the time of COVID-19. Peritoneal Dialysis International. 2020;40(4):357-8. https://doi.org/10.1177/0896860820921657
9. Abdulameer AA, Mohammed ZN, Tawfeeq KT. Endoscopic characteristics and management of Subepithelial Lesions in Video-Gastascopie. Med Pharm J. 2022;1(1):4-13. https://doi.org/10.55940/medphar20221
10. Ellis P. An overview of haemodialysis. British Journal of Nursing. 2023;32(8):356-60.
11. Ito Y, Ryuzaki M, Sugiyama H, Tomo T, Yamashita AC, Ishikawa Y, et al. Peritoneal dialysis guidelines 2019 part 1 (position paper of the Japanese Society for Dialysis Therapy). Renal Replacement Therapy. 2021;7(1):40. https://doi.org/10.1186/s41100-021-00348-6
12. Pei M, Aguiar R, Pagels AA, Heimbürger O, Stenvinkel P, Bárány P, et al. Health-related quality of life as predictor of mortality in end-stage renal disease patients: an observational study. BMC nephrology. 2019;20(1):1-0. https://doi.org/10.1186/s12882-019-1318-x
13. Naji MA, Alburghaif AH, Saleh NK, Al-hussaniy H. Patient expectations regarding consultation with a family doctor: a crosssectional study. Medical and Pharmaceutical Journal. 2022;1(1):35-40. https://doi.org/10.55940/medphar2022-3
14. Rabindranath KS, Nessim SJ, Bargman JM. Small Solute Clearance in Peritoneal Dialysis. Evidence‐Based Nephrology. 2022;2:91-112.
15. Hussein ZR, Omar SK, Mustafa Alkazraji RA, Alsamarrai AN, Alrubaye HS, Al-Hussaniy HA. Efficacy of Aflibercept as initial treatment for neovascular age-related macular degeneration in an Iraqi patient sample. Journal of Medicine & Life. 2023;16(2). https://doi.org//10.25122/jml-2022-0356
16. Jin H, Fang W, Zhu M, Yu Z, Fang Y, Yan H, et al. Urgent-start peritoneal dialysis and hemodialysis in ESRD patients: complications and outcomes. PLoS One. 2016;11(11):e0166181. https://doi.org/10.1371/journal.pone.0166181
17. Li WW, Kuo CT, Hwang SL, Hsu HT. Factors related to medication non‐adherence for patients with hypertension in Taiwan.
Journal of clinical nursing. 2012;21(13-14):1816-24. https://doi.org/10.1111/j.1365-2702.2012.04088.x
18. John JC, Taha S, Bunchman TE. Basics of continuous renal replacement therapy in pediatrics. Kidney research and clinical practice. 2019;38(4):455. https://doi.org/10.23876%2Fj.krcp.19.060
19. Ricci Z, Ronco C. Timing, dose and mode of dialysis in acute kidney injury. Current opinion in critical care. 2011;17(6):556-61. https://doi.org/10.1097/MCC.0b013e32834cd360
20. Schmid H, Hartmann B, Schiffl H. Adherence to prescribed oral medication in adult patients undergoing chronic hemodialysis: a critical review of the literature. European journal of medical research. 2009;14(5):185-90. https://doi.org/10.1186/2047-783X-14-5-185
21. Tan XI, Patel I, Chang J. Review of the four item Morisky medication adherence scale (MMAS-4) and eight item Morisky medication adherence scale (MMAS-8). INNOVATIONS in pharmacy. 2014;5(3):5. https://doi.org/10.1111/ijcp.14717
22. Dinas PC, Koutedakis Y, Flouris AD. Effects of exercise and physical activity on depression. Irish journal of medical science. 2011;180:319-25. https://doi.org/10.1007/s11845-010-0633-9
23. Hossain HU, Aftab A, Soron TR, Alam MT, Chowdhury MW, Uddin A. Suicide and depression in the World Health Organization
South-East Asia region: A systematic review. WHO South-East Asia journal of public health. 2017;6(1):60-6. https://doi.org/10.4103/2224-3151.206167
24. Salim Mahmood A, Ammoo AM, Ali MH, Hameed TM, Al-Hussaniy HA, Aljumaili AA, et al. Antiepileptic Effect of Neuroaid® on Strychnine-Induced Convulsions in Mice. Pharmaceuticals. 2022;15(12):1468. https://doi.org/10.3390/ph15121468
25. Lopes AA, Bragg J, Young E, Goodkin D, Mapes D, Combe C, Piera L, Held P, Gillespie B, Port FK. Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney international. 2002;62(1):199-207. https://doi.org/j.1523-1755.2002.00411.x
26. Eltayeb M, Khalil A, Sany D. Prevalence of depression among hemodialysis patients. Hemodial Int. 2010;14:114. https://doi.org/10.1590/1516-4446-2018-0345 s
27. Khan A, Khan AH, Adnan AS, Sulaiman SA, Mushtaq S. Prevalence and predictors of depression among hemodialysis patients: a prospective follow-up study. BMC public health. 2019;19(1):1-3. https://doi.org/10.1186/s12889-019-6796-z
28. Cohen SD, Sharma T, Acquaviva K, Peterson RA, Patel SS, Kimmel PL. Social support and chronic kidney disease: an update. Advances in chronic kidney disease. 2007;14(4):335-44. https://doi.org/10.1053/j.ackd.2007.04.007
29. de Alencar SB, de Lima FM, Dias LD, Dias VD, Lessa AC, Bezerra JM, et al. Depression and quality of life in older adults on hemodialysis. Brazilian Journal of Psychiatry. 2019;42:195-200. https://doi.org/10.1590/1516-4446-2018-0345
30. Levis B, Sun Y, He C, Wu Y, Krishnan A, Bhandari PM, et al. Accuracy of the PHQ-2 alone and in combination with the PHQ-9 for screening to detect major depression: systematic review and meta-analysis. Jama. 2020;323(22):2290-300. https://doi.org/10.1001/jama.2020.6504
31. Saeed N. Translation and Validation of a Simplified Medication Adherence Questionnaire and Factors Affecting Chronic Diseases Medication Adherence among Arab Americans (Doctoral dissertation, Howard University).
32. Altalebi RR, Al-Hussaniy HA, Al-Tameemi ZS, Al-Zobaidy MA, Albu-Rghaif AH, Alkuraishy HM, et al. Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes. Journal of Medicine & Life. 2023;16(1);42-7. https://doi.org/10.25122/jml-2022-0091
33. Al-Hussaniy HA, Mohammed ZN, Alburghaif AH, Naji MA. Panax ginseng as Antioxidant and Anti-inflammatory to reduce the
Cardiotoxicity of Doxorubicin on rat module. Research Journal of Pharmacy and Technology. 2022;15(10):4594-600.
34. Hadi HM, Shahada AR, Hussein NM, Hussein EHA. Doxorubicin Side Effects and Its Uses a new update: A narrative review. Arabian J. Drug Res. 2021;1(1):1-6. Available from: https://pharmacoj.com/ojs/index.php/AJDR/article/view/64
35. Awad M, Al-Hussaniy HA, Alburghaif AH, Tawfeeq KT. The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention. Journal of Medicine and Life. 2022;15(12):1458. https://doi.org/10.25122/jml-2022-0167
36. Maruyama Y, Higuchi C, Io H, Wakabayashi K, Tsujimoto H, Tsujimoto et, al. Comparison of peritoneal dialysis and hemodialysis as first renal replacement therapy in patients with end-stage renal disease and diabetes: a systematic review. Renal Replacement Therapy. 2019;5(1):1-2.
37. Bruce MA, Beech BM, Sims M, Brown TN, Wyatt SB, Taylor HA, et al. Social environmental stressors, psychological factors, and kidney disease. Journal of Investigative Medicine. 2009;57(4):583-9. https://doi.org/10.2310/jim.0b013e31819dbb91
38. Kadhem ZA. Blood calcium balance and dialysate calcium concentration in heamodialysis patients in Thi-Qar Province, Iraq. University of Thi-Qar Journal Of Medicine. 2014;8(1):39-49.
39. Neugarten J, Acharya A, Silbiger SR. Effect of gender on the progression of nondiabetic renal disease: a meta-analysis. Journal of the American Society of Nephrology. 2000;11(2):319-29. https://doi.org/10.1681/asn.v112319
40. Al-Rishawi M, Al-Juboori AK. Anxiety and Depression Symptoms of Renal Failure Patients undergoing Hemodialysis at Al Sadder Teaching Hospital in Al Amarah City. Kufa J. for Nurs. Sciences. 2015;5(2).
41. Al_hussaniy HA. Medical Scientific Research Challenges in Iraq. Medical and Pharmaceutical Journal. 2023;2(1):1-3.
42. Hommel K, Rasmussen S, Kamper AL, Madsen M. Regional and social inequalities in chronic renal replacement therapy in Denmark. Nephrology Dialysis Transplantation. 2010;25(8):2624-32. https://doi.org/10.1093/ndt/gfq110
43. Atia H, Yasir A, Khuder K. Assessment of Depression for Adult Patients with Hemodialysis. Medical Journal of Babylon.
2012;9(1):60-9.
44. Jungers P, Chauveau P, Descamps-Latscha B, Labrunie M, Giraud E, et al. Age and gender-related incidence of chronic renal failure in a French urban area: a prospective epidemiologic study. Nephrology Dialysis Transplantation. 1996;11(8):1542-6.
45. Muehrer RJ, Schatell D, Witten B, Gangnon R, Becker BN, Hofmann RM. Factors affecting employment at initiation of dialysis. Clinical journal of the American society of nephrology. 2011;6(3):489-96. https://doi.org/10.2215/cjn.02550310
46. Abdul Raheem T, Ali K, Abdul Rasoul S, et al. Depression in Iraqi hemodialysis patients. Arab journal of nephrology and transplantation. 2013;6(3):169-72.
47. Burnier M, Pruijm M, Wuerzner G, et al. Drug adherence in chronic kidney diseases and dialysis. Nephrol Dial Transplant. 2015;30(1):39- 44. https://doi.org/10.1093/ndt/gfu015
48. Al-Hussaniy HA, Mohammed ZN, Alburghaif AH, Naji MA. Panax ginseng as Antioxidant and Anti-inflammatory to reduce the Cardiotoxicity of Doxorubicin on rat module. Research Journal of Pharmacy and Technology. 2022;15(10):4594-600.
49. Abdulmalik M, Sarah M, Najla A. Medication adherence among adult patients on hemodialysis. Saudi J Kidney Dis Transpl. 2014;25(4):762-8. https://doi.org/10.4103/1319-2442.134990
50. Awad M, Al-Hussaniy HA, Alburghaif AH, Tawfeeq KT. The role of COVID-19 in myopathy: incidence, causes, treatment, and prevention. Journal of Medicine and Life. 2022;15(12):1458. https://doi.org/10.25122/jml-2022-0167
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Feb 28, 2025
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Assessment of Adherence to Medications and Prevalence of depression among hemodialysis patients. Pharm Pract (Granada) [Internet]. 2025 Feb. 28 [cited 2025 Apr. 21];23(1):1-10. Available from: https://pharmacypractice.org/index.php/pp/article/view/3087
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How to Cite
1.
Assessment of Adherence to Medications and Prevalence of depression among hemodialysis patients. Pharm Pract (Granada) [Internet]. 2025 Feb. 28 [cited 2025 Apr. 21];23(1):1-10. Available from: https://pharmacypractice.org/index.php/pp/article/view/3087