Side Effects of COVID-19 Vaccines Among Jordanian Females: A Cross-Sectional Study
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Keywords
Coronavirus, COVID-19, Vaccines, side effects, Females, Jordan
Abstract
Background: The rapid development of the COVID-19 vaccine played a critical role in combating the SARS-CoV-2 pandemic. Global vaccination campaigns aimed to achieve widespread immunity, reduce transmission, and reduce mortality rates. However, concerns regarding the vaccine's safety and associated side effects persist, especially among women. Understanding these concerns and reporting the side effects is essential for public health strategies and building confidence in vaccination programs. Methods: A cross-sectional study was conducted in August 2021 to investigate the side effects experienced by Jordanian females. Participants were recruited via social media platforms. The developed study's survey consisted of demographic information and detailed questions about side effects after receiving the COVID-19 vaccine. Data were analyzed using Statistical Package for Social Science (SPSS). Results: A total of 861 females, mainly young adults, participated in the study. The side effects increased among the participants after the second dose, from 44.5% (for the first dose) to 55.5%. The most reported side effects were pain at the injection site, fatigue, and lethargy. Redness at the injection site, cough, and chest pain were more prevalent after the second dose. Residential area was significantly associated with experiencing side effects after the first dose; on the other hand, employment status was significant after the second dose. Conclusion: The present study offers valuable insights into the side effects of COVID-19 vaccines among females. These findings can inform public health strategies and enhance public confidence in vaccination programs in Jordan.
References
prospects. Hum Cell. 2021;34:711–33.
2. Abu-Farha RK, Alzoubi KH, Khabour OF. Public Willingness to Participate in COVID-19 Vaccine Clinical Trials: A Study from
Jordan. Patient Prefer Adherence. 2020;Volume 14:2451–8.
3. Moubarak V, Malaeb D, Mourad N, Younes S, Mayta S, Iskandar K, Sallam M, Obeid S, Hallit S, Hallit R. Knowledge, Practices,
and Psychological Motives of Lebanese Adults Towards Influenza A (H1N1) Vaccination. Jordan Journal of Applied Science -
Natural Science Series. 2024;18:30–6.
4. Arabyat RM, Nusair MB, Al-Azzam SI, Amawi HA, El-Hajji FD. Willingness to pay for COVID-19 vaccines: Applying the health
belief model. Research in Social and Administrative Pharmacy. 2023;19:95–101.
5. Using Telemedicine in Saudi Arabia’s Healthcare System During COVID-19 Pandemic. Jordan Journal of Applied Science -
Natural Science Series. 2023;17.
6. Nassar RI. Short-term Side Effects of mRNA-based COVID-19 Vaccine Among Jordanian Population ; a Cross-sectional Study.
Arch Acad Emerg Med. 2023;11:1–8.
7. Nassar RI, Alnatour D, Thiab S, Nassar A, El-Hajji F, Basheti IA. Short-term side effects of COVID-19 vaccines: A cross-sectional
study in Jordan. Hum Vaccin Immunother. 2022;18.
8. Nassar RI, Barakat M, Thiab S, El-Hajji F, Barqawi H, El-Huneidi W, Basheti I, Abu-Gharbieh E. Web-Based Reporting of Post-
Vaccination Symptoms for Inactivated COVID-19 Vaccines in Jordan: A Cross-Sectional Study. Vaccines (Basel). 2023;11.
9. Abu-Hammad O, Alduraidi H, Abu-Hammad S, Alnazzawi A, Babkair H, Abu-Hammad A, Nourwali I, Qasem F, Dar-Odeh N. Side
Effects Reported by Jordanian Healthcare Workers Who Received COVID-19 Vaccines. Vaccines (Basel). 2021;9:577.
10. Ciarambino T, Barbagelata E, Corbi G, Ambrosino I, Politi C, Lavalle F, Ruggieri A, Moretti A. Gender differences in vaccine
therapy: where are we in COVID-19 pandemic? Monaldi Archives for Chest Disease. 2021;
11. Al-Qazaz HKh, Al-Obaidy LM, Attash HM. COVID-19 vaccination, do women suffer from more side effects than men? A
retrospective cross-sectional study. Pharm Pract (Granada). 2022;20:01–10.
12. Sudharsanan N, Favaretti C, Hachaturyan V, Bärnighausen T, Vandormael A. Effects of side-effect risk framing strategies on
COVID-19 vaccine intentions: a randomized controlled trial. Elife. 2022;11.
13. El-Shitany NA, Harakeh S, Badr-Eldin SM, Bagher AM, Eid B, Almukadi H, Alghamdi B, Alahmad A, Hassan N, Sindi N, Alghamdi
S, Almohaimeed H, Mohammedsaleh Z, Al-Shaikh T, Almuhayawi M, Ali S, El-Hamamsy M. Minor to moderate side effects of
Pfizer-Biontech COVID-19 vaccine among Saudi residents: A retrospective cross-sectional study. Int J Gen Med. 2021;14:1389–
401.
14. Mohammed RA, Garout RM, Wahid S, Ayub F, Firas ZinAlddin LM, Sultan I. A Survey on the Side Effects of Pfizer/BioNTech
COVID-19 Vaccine Among Vaccinated Adults in Saudi Arabia. Cureus. 2021;13.
15. Zucker I, Prendergast BJ. Sex differences in pharmacokinetics predict adverse drug reactions in women. Biol Sex Differ. 2020;
16. Elayeh E, Akour A, Haddadin RN. Prevalence and predictors of self‐medication drugs to prevent or treat COVID‐19: Experience
from a Middle Eastern country. Int J Clin Pract. 2021;75.
17. Cascini F, Pantovic A, Al-Ajlouni Y, Failla G, Ricciardi W. Attitudes, acceptance and hesitancy among the general population
worldwide to receive the COVID-19 vaccines and their contributing factors: A systematic review. EClinicalMedicine.
2021;40:101113.
18. Subedi D, Pantha S, Subedi S, Gautam A, Gaire A, Sapkota D, Sapkota S, Kandel M, Parajuli A, Ghimire H, Ghimire S, Devkota J,
Dhakal S. Perceptions towards COVID-19 Vaccines and Willingness to Vaccinate in Nepal. Vaccines (Basel). 2021;9:1448.
19. ANDRZEJCZAK-Grządko S, CZUDY Z, DONDERSKA M. Side effects after COVID-19 vaccinations among residents of Poland. Vol.
25, European Review for Medical and Pharmacological Sciences. Verduci Editore s.r.l; 2021. p. 4418–21.
20. Maruyama A, Sawa T, Teramukai S, Katoh N. Adverse reactions to the first and second doses of Pfizer-BioNTech COVID-19
vaccine among healthcare workers. Journal of Infection and Chemotherapy. 2022;28:934–42.
21. Saeed BQ, Al-Shahrabi R, Alhaj SS, Alkokhardi ZM, Adrees AO. Side effects and perceptions following Sinopharm COVID-19
vaccination. International Journal of Infectious Diseases [Internet]. 2021;111:219–26. Available from: https://doi.org/10.1016/j.
ijid.2021.08.013
22. Elgendy MO, El-Gendy AO, Mahmoud S, Mohammed TY, Abdelrahim MEA, Sayed AM. Side Effects and Efficacy of COVID-19
Vaccines among the Egyptian Population. Vaccines (Basel). 2022;10:109.
23. Rabail R, Ahmed W, Ilyas M, Rajoka MSR, Hassoun A, Khalid AR, Khan M, Aadil R. The Side Effects and Adverse Clinical Cases
Reported after COVID-19 Immunization. Vaccines (Basel). 2022;10:488.
24. CDC. Possible Side Effects [Internet]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/expect/after.html
25. Dighriri IM, Alhusayni KM, Mobarki AY, Aljerary IS, Alqurashi KA, Aljuaid FA, Alamri K, Mutwalli A, Maashi N, Aljohani A, Alqarni
A, Alfaqih A, Moazam S, Almutairi M, Almutairi A.. Pfizer-BioNTech COVID-19 Vaccine (BNT162b2) Side Effects: A Systematic
Review. Cureus. 2022;14.
26. Ozdemir L, Pιnarcι E, Akay BN, Akyol A. Effect of methylprednisolone injection speed on the perception of intramuscular injection pain. Pain Management Nursing. 2013;14:3–10.
27. CDC. Training and Education Resources|COVID-19 Vaccination. 2021.
28. Portelli B, Scaboro S, Tonino R, Chersoni E, Santus E, Serra G. Monitoring User Opinions and Side Effects on COVID-19 Vaccines
in the Twittersphere: Infodemiology Study of Tweets. J Med Internet Res. 2022;24:e35115.
29. Blumenthal KG, Greenhawt M, Phillips EJ, Agmon-Levin N, Golden DBK, Shaker M. An Update in COVID-19 Vaccine Reactions
in 2023: Progress and Understanding. J Allergy Clin Immunol Pract. 2023;11:3305–18.
30. Hall SE, Holman CDJ, Wisniewski ZS, Semmens J. Prostate cancer: socio‐economic, geographical and private‐health insurance
effects on care and survival. BJU Int. 2005;95:51–8.
31. Clouston SAP, Natale G, Link BG. Socioeconomic inequalities in the spread of coronavirus-19 in the United States: A examination
of the emergence of social inequalities. Soc Sci Med. 2021;268:113554.
32. Nixon AE, Mazzola JJ, Bauer J, Krueger JR, Spector PE. Can work make you sick? A meta-analysis of the relationships between
job stressors and physical symptoms. Work Stress. 2011;25:1–22.
33. Jiang C, Chen Q, Xie M. Smoking increases the risk of infectious diseases: A narrative review. Tob Induc Dis. 2020;18.
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