How to measure (or not) compliance to eradication therapy
This study aimed to test a novel method of compliance measurement in Portuguese community pharmacy in Helicobacter pylori patients.
A case series design was used where compliance indicators were electronically measured, aside with patients’ reports. Experienced adverse drug reactions, perceived benefit of therapy and quality of life were also measured.
Mean compliance proportion was 56% and a positive impact on patients’ perceived health status was found. The method used was welcomed by community pharmacists, albeit having an influence on patients’ normal behaviour.
2 Laporte J.R., Carne X., Vidal X., Moreno V., Juan J. Upper gastrointestinal bleeding in relation to previous use of non-steroidal anti-inflammatory drugs. Catalan Countries Study on Upper Gastrointestinal Bleeding. Lancet 1991; 337(8733):85-89.
3 Unge P. What other regimens are under investigation to treat Helicobacter pylori infection? Gastroenterology 1997;113:137-148.
4 Sackett, D. L. & Haynes, R. B. Compliance with therapeutic regimens. John Hopkins University Press, Baltimore: 1976.
5 Farmer, K. C. Methods for Measuring and Monitoring Medication Regimen Adherence in Clinical Trials and Clinical Practice. Clin Ther 1999; 21(6): 1074-1090.
6 Levenstein S, Kaplan GA, Smith MW. Psychological predictors of peptic ulcer incidence in the Alameda County Study. J Clin Gastroenterol 1997; 24(3):140-146.
7 Cramer, J. A. & Spilker, B. Patient Compliance in Medical Practice and Clinical Trials. Raven Press. New York: 1991.
8 Hennekens, C. H. & Buring, J. E. Descriptive studies in Epidemiology in Medicine, S. L. Mayrent editions. Little, Brown and Company. Boston: 1987.
9 World Health Organisation. Adherence to long-term therapies: evidence for action. Geneva: 2003.
The authors hereby transfer, assign or otherwise convey to Pharmacy Practice (1) the right to grant permission to republish or reprint the stated material, in whole or in part, without a fee; (2) the right to print or epublish copies for free distribution or sale; and (3) the right to republish the stated material in any format (electronic or printed). In addition, the undersigned affirms that the article described above has not previously been published, in whole or part, is not subject to copyright or other rights except by the author(s), and has not been submitted for publication elsewhere, except as communicated in writing to Pharmacy Practice with this document.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-BY-NC-ND) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
Author Self-Archiving Policy
Pharmacy Practice permits and encourages authors to post and archive the final PDFs of their respective articles submitted to the journal on personal websites or institutional repositories after publication, while providing bibliographic details that credit its publication in this journal.