The effect of one-dose package on medication adherence for the elderly care in Japan

  • Kiyohito Nakai
  • Nobuo Yamamoto
  • Miwako Kamei
  • Masahiko Fujita
Keywords: Drug Packaging, Community Pharmacy Services, Medication Adherence, Japan


Deterioration of the medication adherence for elderly could result in wasteful medical expenditure in a long-term span as well as aggravating the patient's medical condition.

Objective: This study surveyed the effect of one-dose package medication made up by a pharmacist on the patient's behavior towards medication, what is expected to be one of the measures to improve the medication adherence for elderly.

Methods: With support activity of the Pharmacist Association in Ueda-city in Nagano Prefecture, Japan, the survey form of one-dose package was sent to 86 pharmacy directors located in Ueda-city.

Results: The most frequent reasons of one dose packaging was “Patient’s request” though, “Large number of doses”, “Prevent the improper drug use” and “Improved medication adherence” which is considered that the pharmacists are willing to utilize one dose package for patient’s care in order to improve the medication adherence were chosen as well. The influences of one dose package for patient’s medication adherence were very positive, and most answers indicated that medication adherence was improved.

Conclusion: It is noticed that the pharmacists were willing to dispense one dose packaging by own decision, not physician’s order, in order to improve the medication adherence, prevent improper drug use and optimize the medication therapy. It is also noticed that there are great improvement of patient’s compliance by one dose package, and patients felt advantage to reduce the improper drug use as well.


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1. Koichiro Harada, Improvement of drug adherence with pharmacist. Circulation Plus 2007;7(11):10-12.

2. Murray MD, Birt JA, Manatunga AK, Darnell JC. Medication compliance in elderly outpatients using twice-daily dosing and unit-of-use packaging. Ann Pharmacother. 1993;27(5):616-621.

3. Ministry of Health, Labor and Welfare, The survey of medical care activity in public health insurance in 2006, (accessed 30-Oct-2008).

4. The monitoring survey of Medicine and the Elderly in 2005, The Woman's Executive Committee, Japan Federation of Senior Citizen's Club.

5. The report for medication adherence in elderly in 2004, Japan Pharmacist Association.

6. Schneider PJ, Murphy JE, Pedersen CA. Impact of medication packaging on adherence and treatment outcomes in older ambulatory patients. J Am Pharm Assoc (2003). 2008;48(1):58-63.

7. Connor J, Rafter N, Rodgers A. Do fixed-dose combination pills or unit-of-use packaging improve adherence? A systematic review. Bull World Health Organ. 2004;82(12):935-939.

8. Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: A systematic review. Arch Intern Med. 2007;167(6):540-550.

9. Special Committee on health care system for the latter-stage elderly of Social Security Council, Medical fee scheme of health care system for the latter-stage elderly, Oct., 10 2007, (accessed 30-Oct-2008).
How to Cite
Nakai K, Yamamoto N, Kamei M, Fujita M. The effect of one-dose package on medication adherence for the elderly care in Japan. Pharm Pract (Granada) [Internet]. 2009Mar.4 [cited 2020Sep.19];7(1):59-2. Available from:
Original Research