The amount of liquid patients use to take tablets or capsules

  • Joerg Fuchs
Keywords: Tablets, Capsules, Counseling, Drug Labeling, Germany


The correct use of pharmaceutical drugs supports therapy success and reduces the number of adverse side effects. One relevant aspect of use concerns the amount of liquid consumed when taking compact and shaped medicines.

Objective: The aim of this study was to investigate the volume of liquid used by patients when administering their medication.

Methods: Every patient who bought tablets or capsules from the study leader in a pharmacy in Jena (Germany), and wanted to take their medicine immediately, received a glass containing 150ml of water. The volume of water consumed by the patients was measured after they took their medication.

Results: 21 out of the 136 participants (15.4%) used only up to 60ml of liquid to take their tablets or capsules. Significant influences of demographic aspects, such as age or gender, on the volume of used liquid were not found. However, an increase in tablet or capsule size led to a significant increase in the volume of swallowed liquid.

Conclusion: Patients need to be better informed about drinking a sufficient amount of liquid when taking tablets or capsules orally. Therefore, it is important that every package insert of compact and shaped medicines contains this information. In addition, medical and pharmaceutical experts should also provide this advice to their patients.


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1. Sale J, Gignac M, Hawker G. How "bad" does the pain have to be? A qualitative study examining adherence to pain medication in older adults with osteoarthritis. Arthritis Care Res. 2006;55:272-278.

2. Gibbs S, Waters WE, George CF. The benefits of prescription information leaflets (1). Br J Clin Pharmacol. 1989;27:723-739.

3. Fuchs J, Hippius M. Inappropriate dosage instructions in package inserts. Patient Educ Couns. 2007;67:157-168.

4. Kelloway JS, Kochevar JW, Sveum RJ, Hahn MA. Evaluation of the Autohaler Actuator: The effect of written patient instructions on correct use. J Asthma. 1993;30:373-379.

5. Quinzler R, Gasse C, Schneider A, Kaufmann-Kolle P, Szecsenyi J, Haefeli WE. The frequency of inappropriate tablet splitting in primary care. Eur J Clin Pharmacol. 2006;65:1065-1073.

6. Fuchs J, Finke A, Hippius M. Wie genau lassen sich Tabletten teilen? Internist Praxis. 2008;48:147-159.

7. Gallo SH, McClave SA, Makk LJK, Looney SW. Standardization of clinical criteria required for use of the 12.5 millimeter barium tablet in evaluating esophageal lumenal patency. Gastrointest Endosc. 1996;2:181-184.

8. Osmanoglou E; Van Der Voort IR; Fach K; Kosch O; Bach D; Hartmann V; Strenzke A; Weitschies W; Wiedenmann B; Trahms L; Mönnikes H. Oesophageal transport of solid dosage forms depends on body position, swallowing volume and pharyngeal propulsion velocity. Neurogastroenterol Motil. 2004;16:547-556.

9. Jaspersen D. Drug-induced oesophageal disorders: pathogenesis, incidence, prevention and management. Drug Saf. 2000;22:237-249.

10. Fuchs J, Hippius M, Schaefer M. Analysis of German package inserts. Int J Clin Pharmacol Ther 2006;44:8-13.

11. Medizinische Medien Informations GmbH. Gelbe Liste Pharmaindex. (accessed June 26, 2009)

12. EMEA. QRD Template centralised procedure version 7.2 and MR/DC/referral procedures 1.2. (accessed March 9, 2009)
How to Cite
Fuchs J. The amount of liquid patients use to take tablets or capsules. Pharm Pract (Granada) [Internet]. 2009Sep.3 [cited 2019Aug.18];7(3):170-4. Available from:
Original Research