Natural agents’ role in cancer chemo-resistance prevention and treatment: molecular mechanisms and therapeutic prospects

Main Article Content

Anas Abed
Malek Zihlif
Heba A Khader
Luai Hasoun
Amniyah Al-Imam
Mahmoud J Al Shawabkeh
Leen B Fino
Alhareth A. Alsa’d
Mustafa Al-Shajlawi
Ahmad R. Alsayed


anti-cancer, natural products, molecular


Cancer is a leading cause of morbidity and mortality worldwide, necessitating exploring novel preventive and therapeutic strategies. Over the years, the potential of natural agents in cancer prevention and treatment has garnered considerable attention. This review highlights the current understanding of the molecular mechanical bases underlying the role of natural agents and their therapeutic potential in combating cancer. The molecular mechanisms through which these natural agents exert their anti-cancer activities are elucidated, encompassing modulation of signaling pathways involved in cell proliferation, apoptosis, angiogenesis, metastasis, and immune response. Additionally, the review delves into the emerging research on the epigenetic modifications induced by natural agents, providing a deeper insight into their anti-cancer properties.

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