Main Article Content
Cross-sectional studies, Drug compounding, Drug stability, Indonesia, Pharmacists
Objective: In extemporaneous compounding, drugs’ stability is indicated by beyond-use date (BUD), which is different from the expiration date determined by manufacturers, hence, pharmacists are required to provide proper BUD information to patients. A recent study showed that BUD knowledge in the North Jakarta community is low, therefore, this study aims to examine the prevalence of Indonesian pharmacists’ BUD knowledge regarding various non-sterile dosage forms. Methods: This cross-sectional study involved Indonesian pharmacists’ knowledge of serving extemporaneous prescriptions. Recruitment was carried out through the purposive and snow-balling sampling method, while data were obtained by filling out a validated authors’ designed questionnaire, with total 34 questions, and collected in September 2021 and then analyzed using the chi-square test. Results: Among the 221 total respondents, 93.7% had BUD knowledge, while 12.7% responded that BUD and expiration date are similar. Regarding BUD for crushed tablets, dry syrup without preservatives, and ointment without moisture, there were 13.1%, 82.8%, and 29.4% responded rightly, respectively. Furthermore, there was no correlation between BUD knowledge and respondents’ characteristics, including health-care workplace and location, as well as gender, and age with p>0.05. Conclusion: Based on the results, the Indonesian pharmacists were considered to have inadequate BUD knowledge, specifically on crushed tablets and ointment, and this might affect drugs’ safety.
2. United States Pharmacopeia. (795) Pharmaceutical Compounding-Nonsterile Preparations. 2020. https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/gc-795-rb-notice-20200424.pdf
3. Badan Pengawas Obat dan Makanan (BPOM). Peraturan Badan Pengawas Obat dan Makanan Nomor 34 tahun 2018 tentang Pedoman Cara Pembuatan Obat yang Baik [Internet]. Badan Pengawas Obat dan Makanan (BPOM). 2018. https://photo.reqnews.com/produk/fc1b308febcec31537273882e9b411e7.pdf
4. Komite Akreditasi Rumah Sakit. Instrumen Survey Akreditasi RS SNARS. 2018 [cited 2021 Feb 6]. https://galihendradita.files.wordpress.com/2018/04/instrumen-snars-pkpo.pdf
5. Pramestutie H, lllahi R, Hariadini A, et al. Factor Associated with the Knowledge Level in the Management of Unused, Damage and Expired Drugs. J Manag Pharm Pract. 11(1):25-38.
6. Cokro F, Arrang ST, Solang JAN, et al. The Beyond-Use Date Perception of Drugs in North Jakarta, Indonesia. Indones J Clin Pharm. 2021;10(3):172-9.
7. Farmalkes S. Rapat Koordinasi Komite Farmasi Nasional 2016 | Direktorat Jenderal Kefarmasian dan Alat Kesehatan. [cited 2021 Feb 24]. https://farmalkes.kemkes.go.id/2016/08/rapat-koordinasi-komite-farmasi-nasional
8. Charan J, Biswas T. How to Calculate Sample Size for Different Study Designs in Medical Research? Indian J Psychol Med. 2013;35(2):121-6. https://doi.org/10.4103/0253-7176.116232
9. Association of Indonesian Pharmacy Higher Education. Academic Script: Graduate Competencies Standard and Pharmacy Education Curriculum Standard for Undergraduate and Apothecary Study Program. 2013.
10. Cokro F, Atmanda PFK, Sagala RJ, et al. REVIEW: Pharmacy Education in Indonesia. Pharm Educ. 2021;21:432-42.
11. Times IDN, Bella K. Ini 7 Fakta yang Harus Kamu Ketahui Tentang Jurusan Farmasi. IDN Times. [cited 2022 Jan 5]. https://www.idntimes.com/life/education/kirana-bella/ini-7-fakta-yang-harus-kamu-ketahui-tentang-jurusan-farmasi-c1c2